Protein Details: G protein-activated inward rectifier potassium channel 2

Protein ID

ICDB_Pro_0546

Protein Name

G protein-activated inward rectifier potassium channel 2

Gene Name

KCNJ6; GIRK2; KATP2; KCNJ7

Organism

Homo sapiens (Human)

Length

423 amino acids

AlphaFoldDB

AF-P48051-F1-model_v4.pdb

Function

This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Sequence

MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENESKV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Keppen-Lubinsky Syndrome and Genetic Lipodystrophy

Location

Most abundant in cerebellum; and to a lesser degree in islets and exocrine pancreas.

DOI ID

10.1074/jbc.270.44.26086; 10.1016/s0898-6568(99)00059-5; 10.1101/gr.2596504; 10.1016/0014-5793(95)00498-x; 10.2337/diab.44.5.592; 10.1016/j.ajhg.2014.12.011

RefSeq

NP_002231.1